Lab Basis

Determining the proper protocol; serotonin or dopamine23-36

Serotonin and dopamine are filtered from the blood by the glomerulus of the kidneys. Under normal conditions, all filtered serotonin and dopamine are subject to metabolization; none makes it to the final urine. Next, serotonin and dopamine precursors filtered at the glomerulus are synthesized into new serotonin and dopamine. Kidney transporters then process and transport the newly synthesized serotonin and dopamine by sending them to the peripheral system or the final urine.

Why urinary serotonin and dopamine assay establishes if
the hypodopaminergic or hyposerotonergic condition protocol is required

Low serotonin symptoms may be identical to low dopamine dopamine

PATIENTS NEED TO BE ON LEVEL-3 of the serotonin protocol for proper testing to occur.

The figure to the right illustrates a dual-gate lumen transporter, which transports and determines how much newly synthesized kidney serotonin and dopamine is processed to either the peripheral system or urine. In the illustration, the serotonin gate is partially closed, shunting serotonin to the final urine; the dopamine gate is fully open preferentially, sending dopamine to the peripheral system. This configuration occurs when the peripheral system requires a significant increase in dopamine. Conversely, excluding serotonin transport to the peripheral system causes large amounts of serotonin to appear in the urine when there are significant unmet peripheral dopamine needs. With this lab approach, objective determination of which protocol (hyposerotonergic or hypodopaminergic condition protocol) is facilitated.

When the patient has been on level-3 of the serotonin protocol for seven days and still has symptoms with a urinary serotonin >5,000 μgr/gr cr, change the patient to the hypodopaminergic (low dopamine) condition protocol.

Gate Lumen Regulatoin

To obtain kits for lab sample transport, call DBS Labs at +1-877-476-7229