Hypodopaminergic Side Effects

Monoamine List


The foundation of these side effect management protocols are
clinical experience and statistical analysis of over two million patient days of de-identified data from over 1,100 medical practices.

A PARADOXICAL REACTION is an effect of a chemical substance that is opposite to what would usually be expected. Unlike paradoxical reactions associated with hyposerotonergic conditions, which occur the first week, hypodopaminergic conditions, paradoxical reactions generally occur in the 28.0 to the 38.0-gram range and are marked by symptoms worsening. Therefore, proper management is to increase the MMF daily dosing value by 2.4 grams. Then, if in one-week exacerbation of symptoms continues, increase the MMF a second time by 2.4 gram34

HYPOSEROTONERGIC SIDE EFFECT EXACERBATION Literature notes the side effects of headache, anxiousness, insomnia, and palpitations associated with L-dopa, the active ingredient of mucuna pruriens. Clinical experience with this approach reveals when the daily L-dopa dosing is between 24 and 36 grams per day; these side effects may display. As with any new onset of symptoms, a differential diagnosis must be formulated, including hyposerotonergic condition-induced side effects. If a medical workup of other etiologies is indicated, an empirical trial may occur simultaneously where the R&R is increased by one tablet per day. If in one-week symptoms are still present, add a second R&R per day. When the patient claims they have palpitations, the patient needs a cardiac workup. If there is no tachycardia, chest pain, or shortness of breath associated with the palpitations, demonstrating cardiac findings on workup is rare.35-41

A few patients taking L-dopa, the active ingredient of mucuna pruriens on a long-term basis (3 to 7 years), may develop side effects. Literature specifically notes, “The most common side effects in older patients taking levodopa can be confusion, hallucinations, delusions, psychosis, and agitation.” These five things (confusion, hallucinations, delusions, psychosis, and agitation) are specifically listed, in the literature, as an L-dopa side effect, not a disease, still a differential diagnosis needs to be formulated. Proper management of these L-dopa exacerbated hyposerotonergic conditions increases the R&R to level-1 of the hyposerotonergic condition protocol (3 R&R AM and 4 PM). If symptoms are still present in one week, increase to level-2 (3 R&R AM and noon, with 2 R&R Sans at 4 PM). If symptoms are still present in one week, increase to level-3 (3 R&R AM and noon, with 4 R&R Sans at 4 PM). While this problem generally develops after several years, rare cases may occur in the first few months of care.35

LAB TESTING Six weeks after starting the hypodopaminergic condition protocol, submit a specimen to DBS Labs requesting serotonin and dopamine analysis with consult. Testing looks for dopamine fluctuations. Improper management of dopamine fluctuations leads to an inability to stabilize the patient long-term secondary to waxing and waning symptoms. See the hyposerotonergic condition protocol brochure for discussion of renal physiology supporting this testing.

Combo Display Bottles

Mucuna Medical FoodTM
Active ingredient L-dopa
Contains no carbidopa.
For the management of hypodopaminergic
conditions when the modified normal diet does
not meet the system’s needs.
Due to the ability to L-dopa to deplete
serotonin and thiol concomitant adminitration
with R&R is recommend.

Mucuna Medical Food

Related topics covered else where:

  1. Pill Stops
  2. Nutritional deficiency accompanying Pakrinson’s Disease
  3. L-dopa induced glutathione (thiol) depletion
  4. L-dopa induced serotonin depletion Bibliography found at: https://hinzmedicalfoods.com/dopamine
  5. Too much or too little mucuna looks the same
  6. Hormone side effect accompanying medical foods